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GIP (glucose-dependent insulinotropic polypeptide) also enhances insulin secretion and appears to support metabolic efficiency and fat regulation

The benefit with GLP-1s appeared even greater among individuals at highest risk due to family history, genetic predisposition or other high-risk comorbidities, such as Crohns disease or ulcerative colitis

Nevertheless, these outcomes are contradictory, and no research to date has established a conclusive determination in this area